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Novel mutation c.1210-3C>G in with a poly-T tract of 5T affects mRNA splicing in a Chinese patient
Frontiers of Medicine 2022, Volume 16, Issue 1, Pages 150-155 doi: 10.1007/s11684-021-0846-5
Keywords: cystic fibrosis CFTR splicing mutation minigene
Mutation profiling of 16 candidate genes in
Yang Zhang, Fang Wang, Xue Chen, Wenjing Liu, Jiancheng Fang, Mingyu Wang, Wen Teng, Panxiang Cao, Hongxing Liu
Frontiers of Medicine 2019, Volume 13, Issue 2, Pages 229-237 doi: 10.1007/s11684-018-0616-1
Frontiers of Medicine 2022, Volume 16, Issue 4, Pages 627-636 doi: 10.1007/s11684-020-0815-4
Keywords: RUNX1 gene mutation acute myeloid leukemia transcriptional repression DNA methylation
Solving Knapsack Problem by Hybrid Particle Swarm Optimization Algorithm
Gao Shang,Yang Jingyu
Strategic Study of CAE 2006, Volume 8, Issue 11, Pages 94-98
Keywords: particle swarm algorithm knapsack problem genetic algorithm mutation
Dynein axonemal heavy chain 10 deficiency causes primary ciliary dyskinesia in humans and mice
Frontiers of Medicine Pages 957-971 doi: 10.1007/s11684-023-0988-8
Keywords: DNAH10 mice motile cilia mutation primary ciliary dyskinesia
Dong Wang, Min Tian, Guanglin Cui, Dao Wen Wang
Frontiers of Medicine 2018, Volume 12, Issue 3, Pages 319-323 doi: 10.1007/s11684-017-0553-4
Keywords: antithrombin deficiency protein C activity mutation variant venous thromboembolism anticoagulants
Frontiers of Medicine doi: 10.1007/s11684-023-1016-8
Keywords: p53 mutation triple-negative breast cancer decitabine DNMT1 IRF7 innate immune response
Dual faces of SH2-containing protein-tyrosine phosphatase
Shuangwei Li, Diane DiFang Hsu, Hongyang Wang, Gen-Sheng Feng
Frontiers of Medicine 2012, Volume 6, Issue 3, Pages 275-279 doi: 10.1007/s11684-012-0216-4
PTPN11, which encodes tyrosine phosphatase Shp2, is a critical gene mediating cellular responses to hormones and cytokines. Against original prediction as tumor suppressor for tyrosine phosphatases, PTPN11 was first identified as a proto-oncogene because activating mutations of this gene are associated with leukemogenesis. However, most recent experimental data suggest PTPN11/Shp2 acting as a tumor suppressor in hepatocarcinogenesis. This review focuses on the tumor-promoting or suppressing roles of the gene PTPN11/Shp2 in different cell types.
Keywords: PTPN11/Shp2 leukemia hepatocellular carcinoma mutation
AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches
Megan A. Hatlen, Lan Wang, Stephen D. Nimer
Frontiers of Medicine 2012, Volume 6, Issue 3, Pages 248-262 doi: 10.1007/s11684-012-0206-6
The AML1-ETO fusion transcription factor is generated by the t(8;21) translocation, which is present in approximately 4%–12% of adult and 12%–30% of pediatric acute myeloid leukemia (AML) patients. Both human and mouse models of AML have demonstrated that AML1-ETO is insufficient for leukemogenesis in the absence of secondary events. In this review, we discuss the pathogenetic insights that have been gained from identifying the various events that can cooperate with AML1-ETO to induce AML in vivo. We also discuss potential therapeutic strategies for t(8;21) positive AML that involve targeting the fusion protein itself, the proteins that bind to it, or the genes that it regulates. Recently published studies suggest that a targeted therapy for t(8;21) positive AML is feasible and may be coming sometime soon.
Keywords: AML1-ETO mouse model leukemia t(8 21) pathway hits mutation hematopoiesis Kasumi-1 CD34+
662 A/G gene variation in human tumor necrosis factor receptor superfamily, member 9 (TNFRSF9)
QU Yanchun, YANG Ze, SUN Liang, JI Linong
Frontiers of Medicine 2008, Volume 2, Issue 3, Pages 283-285 doi: 10.1007/s11684-008-0053-7
Keywords: D-HPLC mutation development autoimmune PCR-RFLP candidate
Monitoring checkpoint inhibitors: predictive biomarkers in immunotherapy
Min Zhang, Jingwen Yang, Wenjing Hua, Zhong Li, Zenghui Xu, Qijun Qian
Frontiers of Medicine 2019, Volume 13, Issue 1, Pages 32-44 doi: 10.1007/s11684-018-0678-0
Immunotherapy has become the fourth cancer therapy after surgery, chemotherapy, and radiotherapy. In particular, immune checkpoint inhibitors are proved to be unprecedentedly in increasing the overall survival rates of patients with refractory cancers, such as advanced melanoma, non-small cell lung cancer, and renal cell carcinoma. However, inhibitor therapies are only effective in a small proportion of patients with problems, such as side effects and high costs. Therefore, doctors urgently need reliable predictive biomarkers for checkpoint inhibitor therapies to choose the optimal therapies. Here, we review the biomarkers that can serve as potential predictors of the outcomes of immune checkpoint inhibitor treatment, including tumor-specific profiles and tumor microenvironment evaluation and other factors.
Keywords: immune checkpoint companion diagnosis PD-L1 tumor mutation burden immune score
Frontiers of Medicine Pages 889-906 doi: 10.1007/s11684-023-0994-x
Keywords: central nervous system lymphoma whole-genome sequencing TMSB4X copy number variation gene mutation
Considerations on Innovation in the Development of Nuclear Agricultural Sciences
Wang Zhidong,Gao Meixu
Strategic Study of CAE 2008, Volume 10, Issue 1, Pages 86-90
Keywords: nuclear agricultural sciences mutation breeding isotope application food irradiation sterile insect technique
Xiao-qing ZHANG, Zheng-feng MING
Frontiers of Information Technology & Electronic Engineering 2017, Volume 18, Issue 11, Pages 1705-1719 doi: 10.1631/FITEE.1601555
Keywords: Swarm intelligence Grey wolf optimizer Optimization Radial basis function network
Growth suppression of colorectal cancer expressing S492R EGFR by monoclonal antibody CH12
Qiongna Dong, Bizhi Shi, Min Zhou, Huiping Gao, Xiaoying Luo, Zonghai Li, Hua Jiang
Frontiers of Medicine 2019, Volume 13, Issue 1, Pages 83-93 doi: 10.1007/s11684-019-0682-z
Keywords: S492R EGFR ectodomain mutation colorectal cancer mAb CH12 immunnotherapy
Title Author Date Type Operation
Novel mutation c.1210-3C>G in with a poly-T tract of 5T affects mRNA splicing in a Chinese patient
Journal Article
Mutation profiling of 16 candidate genes in
Yang Zhang, Fang Wang, Xue Chen, Wenjing Liu, Jiancheng Fang, Mingyu Wang, Wen Teng, Panxiang Cao, Hongxing Liu
Journal Article
Distinct gene expression pattern of mutations coordinated by target repression and promoter hypermethylation in acute myeloid leukemia
Journal Article
Solving Knapsack Problem by Hybrid Particle Swarm Optimization Algorithm
Gao Shang,Yang Jingyu
Journal Article
Dynein axonemal heavy chain 10 deficiency causes primary ciliary dyskinesia in humans and mice
Journal Article
Antithrombin deficiency and decreased protein C activity in a young man with venous thromboembolism: a case report
Dong Wang, Min Tian, Guanglin Cui, Dao Wen Wang
Journal Article
Decitabine induces -mediated immune responses in p53-mutated triple-negative breast cancer: a clinical and translational study
Journal Article
Dual faces of SH2-containing protein-tyrosine phosphatase
Shuangwei Li, Diane DiFang Hsu, Hongyang Wang, Gen-Sheng Feng
Journal Article
AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches
Megan A. Hatlen, Lan Wang, Stephen D. Nimer
Journal Article
662 A/G gene variation in human tumor necrosis factor receptor superfamily, member 9 (TNFRSF9)
QU Yanchun, YANG Ze, SUN Liang, JI Linong
Journal Article
Monitoring checkpoint inhibitors: predictive biomarkers in immunotherapy
Min Zhang, Jingwen Yang, Wenjing Hua, Zhong Li, Zenghui Xu, Qijun Qian
Journal Article
Analysis of the genomic landscape of primary central nervous system lymphoma using whole-genome sequencing in Chinese patients
Journal Article
Considerations on Innovation in the Development of Nuclear Agricultural Sciences
Wang Zhidong,Gao Meixu
Journal Article
An optimized grey wolf optimizer based on a mutation operator and eliminating-reconstructing mechanism
Xiao-qing ZHANG, Zheng-feng MING
Journal Article